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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RYR1
All Species:
10.61
Human Site:
S2753
Identified Species:
46.67
UniProt:
P21817
Number Species:
5
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P21817
NP_000531.2
5038
565176
S2753
I
I
P
E
K
L
D
S
F
I
N
K
F
A
E
Chimpanzee
Pan troglodytes
XP_514296
5018
570278
Y2765
T
I
P
E
K
L
E
Y
F
I
N
K
Y
A
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536330
4972
565017
Y2713
T
I
P
E
K
L
E
Y
F
I
N
K
Y
A
E
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001921137
4882
552681
F2694
T
I
P
E
S
L
E
F
V
V
N
K
Y
A
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24498
5127
580994
S2849
H
L
D
N
D
L
N
S
L
V
Q
K
F
S
E
Honey Bee
Apis mellifera
XP_392217
5083
576621
Q2811
V
L
N
N
D
L
N
Q
I
V
Q
K
F
S
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
65.5
N.A.
65.4
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
55.5
N.A.
45.8
46.2
N.A.
N.A.
Protein Similarity:
100
80
N.A.
79.8
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
71.5
N.A.
63.8
64.8
N.A.
N.A.
P-Site Identity:
100
73.3
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
33.3
26.6
N.A.
N.A.
P-Site Similarity:
100
86.6
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
73.3
N.A.
60
60
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
67
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
17
0
34
0
17
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
67
0
0
50
0
0
0
0
0
0
0
100
% E
% Phe:
0
0
0
0
0
0
0
17
50
0
0
0
50
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
17
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
17
67
0
0
0
0
0
0
17
50
0
0
0
0
0
% I
% Lys:
0
0
0
0
50
0
0
0
0
0
0
100
0
0
0
% K
% Leu:
0
34
0
0
0
100
0
0
17
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
17
34
0
0
34
0
0
0
67
0
0
0
0
% N
% Pro:
0
0
67
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
17
0
0
34
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
17
0
0
34
0
0
0
0
0
34
0
% S
% Thr:
50
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
17
0
0
0
0
0
0
0
17
50
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
34
0
0
0
0
50
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _